Dr. Wu works actively on a number of topics in data management, data analysis, and high-performance computing. His algorithmic research work includes bitmap indexing techniques for searching large datasets, statistical methods for extract features from a variety of data, and restarting strategies for computing extreme eigenvalues.
He is the developer of a number of software packages, including, IDEALEM, SDS, FastBit and TRLan. Among them, the FastBit software for indexing large datasets has earned an R&D 100 Award, and is used by many organizations. For example, a German bioinformatics company uses FastBit to accelerate their molecular docking software by hundreds times.