Yi-Hsiang Hsu, Director of the GeriOMICS Center at HSL Institute for Aging Research

Yi-Hsiang Hsu

Director of the GeriOMICS Center, HSL Institute for Aging Research

Dr.. Yi-Hsiang Hsu is the Director of the GeriOMICS Center, HSL Institute for Aging Research, Beth Israel Deaconess Medical Center, Boston, MA. He is an Associate Professor at Harvard Medical School and at Program for Quantitative Genomics, Program of Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA. He is also an Associate Faculty Member at the BROAD Institute of MIT and Harvard, Cambridge, MA.

Dr. Hsu is a Statistical Geneticist/Computational Biologist. His research focuses on (1) Genetic contribution of common aging relevant disorders (such as osteoporosis, sarcopenic obesity, metabolic syndrome, type 2 diabetes and hypertension) using population-based next generation (NGS) whole genome sequencing, exome-sequencing and genome-wide association (GWAS) approaches to identify common and rare variants that are associated with these complex traits/phenotypes; (2) Predicting non-coding causal variants and targeted genes in GWAS loci using tissue-and cell-specific gene regulatory landscapes generated by ENCODE and US NIH Roadmap Epigenomics Project; (3) Statistical method development on multiple-phenotype association analyses; (4) Integrating omics data (genomics, transcriptome, epigenomics, proteomics and metabolomics) using system genetics and bioinfomatic approaches; and (4) Identifying biomarkers of osteoporosis using metabolomics.


Identify Disease-Associated Genetic Variants Via 3D Genomics Structure and Regulatory Landscapes Using Deep Learning Frameworks

Whole genome sequencing (WGS) has enabled us to quantify human genomic variation at whole genome scale. This has profound impact on improving our understanding of human diversity, health, and diseases. One promising application of WGS… Read more