My Life’s work is in modeling and translating computational systems to practical applications in genetics. I have built genome annotation engines that are used to better understand micro-organisms. This has applications in bio-energy, bio-terroism, and in monitoring and preventing clinical outbreaks. I have also applied these skills in building novel annotation engines for analyzing human variation. In a clinical setting, we wish to know if a variation could cause disease versus occurring naturally in the population; and we wish to filter millions of variants to find those most likely to cause disease.